PKM2 anticorps (AA 36-40)

N° du produit ABIN871666

Cet anticorps Lapin Polyclonal détecte spécifiquement PKM2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour PKM2 anticorps (AA 36-40) (ABIN871666)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PKM2 anticorps

Épitope: AA 36-40

Specificité: The antibody detects endogenous levels of total PKM1/2 protein.

Purification: Affinity purified

Immunogène: Peptide sequence around AA 36-40 (D-S-P-P-I) derived from Human PKM1, 2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Information d'application

Indications d'application: Western blotting: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: PKM2

Sujet: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Poids moléculaire: 60 kDa

ID gène: 5315

NCBI Accession: NP_872270

UniProt: P14618

Pathways: L'effet Warburg